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. Author manuscript; available in PMC: 2017 May 23.

Published in final edited form as: Receptors Clin Investig. 2016 May 23;3(2):e1310.

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The ROS-dependent S-glutathionylation of MVP triggers the binding of the MYH9 complex along with vascular protein sorting 34 (Vps34) and Beclin-1 to the vault complex, inhibiting Beclin-1-dependent cell death. Glutaredoxin 1 (Grx1) and thioredoxin (Trx), which inhibit this cell survival mechanism, enhance smooth muscle cell death.