Skip to main content
. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: Cancer Cell. 2011 Jun 14;19(6):728–739. doi: 10.1016/j.ccr.2011.05.011

Figure 5. Senescence markers are a feature of low-grade mPanINs, but disappear in high-grade mPanIN2/3 and mPDAC.

Figure 5

(A-C) Senescence associated β-galactosidase (SA-β-Gal) staining (blue) in (A) low-grade mPanIN1 but not in (B) high-grade mPanIN2/3 or (C) mPDAC.

(D-F) p16Ink4a immunostaining (brown) in (D) low-grade mPanIN1 but not in (E) high-grade mPanIN2/3 or (F) mPDAC.

(G-I) Ki67 immunostaining (brown) inversely correlates with the expression of the above senescence markers. Ki67 is detected in a low percentage of cells of low-grade mPanIN1 (G) and in a high percentage of cells of high-grade mPanIN2/3 (H) and mPDAC (I).

Note that panels D-G, E-H and F-I correspond to serial sections. Scale bar represents 50 μm.

See also Figure S4.