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. 2016 Jun 2;11(6):e0156493. doi: 10.1371/journal.pone.0156493

Fig 2. Phenserine mitigates mTBI-induced impairments in visual and spatial memory.

Fig 2

(A) mTBI mice demonstrate a deficit in visual memory compared with control (**p<0.01). Phenserine administration, at both doses utilized in this study significantly ameliorated behavioral deficits (##p<0.01). One-way ANOVA revealed a significant effect between groups [F(5,98) = 7.770, p = 0.000]. Fisher’s LSD post hoc analysis revealed that the preference index of the “mTBI” group was significantly lower than all other groups (**p<0.01). (B) mTBI mice demonstrate a significant deficit in spatial memory compared with control (**p<0.01). Phenserine administration significantly ameliorated this damage (##p<0.01 for 2.5mg/kg, and #p<0.05 for 5mg/kg). One-way ANOVA revealed a significant effect between groups [F(5,105) = 6.190, p = 0.000]. Fisher’s LSD post hoc analysis revealed that the preference index of the “mTBI” group was significantly lower than all other groups, other than “Phenserine only” 5 mg/kg (*p<0.05, **p<0.01).