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. 2016 Jun 2;11(6):e0156534. doi: 10.1371/journal.pone.0156534

Table 1. Association of personal characteristics at enrollment with mean Physical Component Summary (PCS) and Mental Component Summary (MCS) scores from the VR-12, for survivors at 5 year follow-up in the Seattle Colorectal Cancer Family Registry.

N (%) PCS MCS
Difference in Mean PCS (95%CI) P Difference in Mean MCS (95%CI) P
Age (y)a
<50 228 (22) ref. <0.001 ref <0.001
50–59 272 (27) -1.5 (-3.4, 0.3) 2.6 (1.1, 4.1)
60–69 337 (33) -3.1 (-5.0, -1.2) 4.5 (3.0, 6.0)
≥70 184 (18) -5.9 (-8.0, -3.7) 3.7 (1.9,5.4)
Sex 0.001 0.001
Male 530 (52) ref ref
Female 491 (48) -2.3 (-3.6, -0.9) -1.7 (-2.8, -0.7)
BMI (kg/m2)b <0.001 0.70
<25 335 (33) ref ref
25–29.9 408 (40) -0.9 (-2.4, 0.6) -0.3 (-1.5, 0.9)
≥30 278 (27) -3.7 (-5.6, -1.9) 0.2 (-1.2, 1.6)
Marital Statusa 0.49 0.66
Not married 259 (25) -0.5 (-2.1, 1.0) -0.3 (-1.5, 1.0)
Married or living as married 762 (75) ref ref
Race 0.22 0.73
White 933 (91) ref -0.3 (-2.2, 1.6)
Other 88 (9) 1.3 (-0.8, 3.4) ref
Educationa <0.001 0.19
High school or less 318 (31) -1.5 (-3.2, 0.3) -0.6 (-1.9, 0.8)
Some college or technical education 335 (33) ref ref
College graduate 368 (36) 2.4 (0.8, 4.0) 0.6 (-0.6, 1.7)
Cigarette Smokinga <0.001 0.11
Never 414 (41) ref ref
Former 502 (49) -1.5 (-2.9, -0.1) -0.3 (-1.4, 0.8)
Current 105 (10) -5.5 (-8.1, -2.9) -2.3 (-4.5, 0.2)
Colorectal Co-morbiditiesa,c 0.049 0.16
None 837 (82) ref ref
One or more 184 (18) -1.8 (-3.5, 0.0) -1.0 (-2.4, 0.4)
Diabetesa,d <0.001 0.18
No 899 (88) ref ref
Yes 122 (12) -5.0 (-7.4, -2.6) -1.2 (-2.9, 0.6)
Stage at Diagnosis 0.12 0.57
Local 517 (51) ref ref
Regional 454 (44) -0.5 (-1.9, 0.9) -0.8 (-1.9, 0.2)
Distant 30 (3) -1.1 (-5.7, 3.6) 1.9 (-0.2, 4.1)
Unstaged or unknown 20 (2) -6.3 (-11.6, -1.1) -0.8 (-4.7, 3.1)
Site of Tumor 0.59 0.74
Colon 619 (61) ref ref
Rectum 349 (34) -0.7 (-2.1, 0.7) 0.2 (-0.9, 1.3)
Unknown 53 (5) -0.8 (-3.9, 2.3) -0.7 (-2.9, 1.6)
Intercept e 52.5 (50.4, 54.8) 53.2 (51.4, 55.1)

a At Colon Cancer Family Registry enrollment.

b Two years prior to baseline interview.

c Self-report of physician diagnosis of colitis, Crohns disease, diverticulitis, or irritable bowel syndrome.

d Self-report of physician diagnosis of diabetes.

e The intercept from the linear regression model is the mean PCS and MCS among (hypothetical) individuals in the referent category for all variables.