Table 1. Cytokine response in lung homogenates, BALF and plasma of WT and Trem-2^-/- mice during experimental melioidosis.

	T = 72h
	WT	Trem-2-/-
pg/ml	Lung homogenate
TNF-α	1680 ± 222	512 ± 156 **
IL-6	7025 ±1408	450 ± 66*
KC	59588 ± 9304	10580 ± 2233**
IL-1β	31292 ± 4975	1860 ± 516**
	BALF
TNF-α	7054 ± 1578	1689 ± 171*
IL-6	18478 ± 4471	406 ± 204 **
KC	30702 ± 6626	1055 ± 454**
IL-1β	10469 ± 2424	217 ± 81**
	Plasma
TNF-α	2324 ± 909	91 ± 19**
IL-6	2641 ± 526	31 ± 5**
IL-10	11 ± 3	5 ± 0**
MCP-1	1675 ± 453	11 ± 1**
IFN-γ	158 ± 62	17 ± 3**
IL-1β	1123 ± 303	125 ± 25*

Cytokine levels in lung homogenate, broncho-alveolar fluid (BALF) and plasma were measured after intranasal infection with 5 x 102 CFU wild-type B. pseudomallei. Wild-type (WT) and Trem-2^-/- mice were sacrificed 72 h after infection. Data are represented as means ± SEM (n = 5-6/group). TNF-α = Tumor necrosis factor-α; IL = Interleukin; MCP-1 = Monocyte Chemoattractant Protein-1; KC = Keratinocyte Chemoattractant; IFN-γ = Interferon-γ

* P< 0.05

** P< 0.01.