Table 2.
Inclusion criteria for the retrieved references
| Indicator | Description |
| I1 | ≥80% of included patients were adults with intravascular (hypovolaemia) or interstitial (dehydration) fluid deficit in the context of any operative or interventional procedure or an intensive care treatment. They did not have chronic renal failure requiring dialysis. |
| I2 | Therapeutic intervention: intravascular fluid therapy with colloids (no dextrans) or crystalloids compared against each other or against placebo with regard to elimination or course of the fluid deficit and to patient-relevant endpoints1) or diagnostic intervention: diagnoses of hypovolaemia or dehydration by the use of specified criteria or diagnostic procedures1) |
| 1)Mortality/survival: ICU, hospital, specified period and risk adjusted. Morbidity: hypervolemia, organ failure, acid base disturbance, allergic reactions, coagulopathy, abdominal compartment, sepsis, pruritus and impaired wound healing. Quality of life. Surrogates: fluid balance; ventilator or vasopressor-free days; vasopressor dosage; volume, pressure, or flow-based variables; dynamic methods (SVV, passive leg raising, etc.); clinical signs of hypoperfusion; metabolic variables (ScvO2, lactate, etc.); microcirculatory parameters | |
| I3 | Article describes a randomized controlled trial, a quasi-randomised controlled trial, a clinical controlled trial, a prospective cohort study, a cross-sectional study or a systematic review/meta-analysis including the study types mentioned |
| I4 | Sample size: n ≥ 20 (n < 20 possible for clinical studies focussing on adverse events) |
| I5 | The reference was published between 1995 and the day of the literature search |
| I6 | The article is written in English or German |
| I7 | The reference is not an additional publication without additional infomation |
| I8 | The full-text study can be acquired |
| I9 | The infusion used is approved for use in Germany (including off label use) |
| I10 | The article was not retracted and the verisimilitude is not doubted. In systematic reviews, retracted or dubious studies can be separated |
| I11 | The article allows comparison of the study with others with regard to methodology, reporting, and internal validity |
A reference that violated a single criterion was excluded.
ScvO2, central venous oxygen saturation; SVV, stroke volume variation.