Table 1.
In vitro Huntington's disease models.
| Cell line | Number of glutamines in the polyQ tract | Full- length/truncated mutant protein | Reporter | Reference |
|---|---|---|---|---|
| HEK-293 | 82 | N-Terminal part of Htt protein with 171 amino acids | None | [14] |
|
| ||||
| HeLa A 459 Sh-SY5Y |
128 | N-Terminal part of Htt protein with 171 amino acids | Enhanced green fluorescent protein | [15] |
|
| ||||
| Cos-7 SH-SY5Y neuro-2A |
49, 72, 151 | Full length of exon-1 | Enhanced green fluorescent protein | [4] |
|
| ||||
| HEK 293 | 60, 150 | N-Terminal part of exon-1 | Enhanced green fluorescent protein | [16] |
|
| ||||
| PC-12 | 103 | N-Terminal part of exon-1 | Ecdysone inducible system | [17] |
|
| ||||
| HEK 293 PC-12 |
150 | N-Terminal part of exon-1 | None | [7] |