Table 1.
In vitro Huntington's disease models.
Cell line | Number of glutamines in the polyQ tract | Full- length/truncated mutant protein | Reporter | Reference |
---|---|---|---|---|
HEK-293 | 82 | N-Terminal part of Htt protein with 171 amino acids | None | [14] |
| ||||
HeLa A 459 Sh-SY5Y |
128 | N-Terminal part of Htt protein with 171 amino acids | Enhanced green fluorescent protein | [15] |
| ||||
Cos-7 SH-SY5Y neuro-2A |
49, 72, 151 | Full length of exon-1 | Enhanced green fluorescent protein | [4] |
| ||||
HEK 293 | 60, 150 | N-Terminal part of exon-1 | Enhanced green fluorescent protein | [16] |
| ||||
PC-12 | 103 | N-Terminal part of exon-1 | Ecdysone inducible system | [17] |
| ||||
HEK 293 PC-12 |
150 | N-Terminal part of exon-1 | None | [7] |