Table 1.
Reported 5-year survival rates in patients undergoing liver transplantation for HCC meeting proposed extended criteria (based on pretransplant versus posttransplant staging).
| Author (year) | Proposed criteria | Pre-LT staging | Explant histology |
|---|---|---|---|
| Yao et al. (2001) [88] | One tumor ≤6.5 cm or ≤3 tumors each ≤4.5 cm Total tumor diameter ≤8.5 cm |
75.2% | |
|
| |||
| Cillo et al. (2004) [94] | Any size and number No poorly differentiated tumor |
75% | |
|
| |||
| Kneteman et al. (2004) [114] | One single tumor <7.5 cm or any number <5 cm Sirolimus as immunosuppressant |
82.9% (4-year-survival) | |
|
| |||
| Ito et al. (2007) [95] | ≤10 tumor nodules Tumor diameter ≤5 cm PIVKA ≤400 mAU/mL (LDLT) |
86.7% | |
|
| |||
| Onaca et al. (2007) [115] | One tumor ≤6 cm or ≤4 tumors each ≤5 cm |
>60% | |
|
| |||
| Lee et al. (2008) [96] | ≤6 tumor nodules Tumor diameter ≤5 cm No gross vascular invasion (LDLT) |
76.3% | |
|
| |||
| Herrero et al. (2008) [97] | One tumor ≤6 cm or ≤3 tumors ≤5 cm No macrovascular invasion No extrahepatic spread |
70% | |
|
| |||
| Zheng et al. (2008) [113] | Total tumor diameter ≤8 cm or total tumor diameter >8 cm, Well differentiated, and AFP ≤400 ng/mL No macrovascular invasion |
72.3% | |
|
| |||
| Mazzaferro et al. (2009) [98] | Sum of size (largest tumor) and number of nodules = 7 (up-to-seven) No microvascular invasion |
71.2% | |
|
| |||
| Muscari et al. (2009) [99] | ≤5 tumor nodules Tumor diameter ≤5 cm |
77% | 76% |
|
| |||
| Fujiki et al. (2009) [139] | ≤10 tumor nodules Tumor diameter ≤5 cm DCP values ≤ 400 mAU/mL |
89% | |
|
| |||
| Dubay et al. (2011) [100] | Any size and number No poor differentiated tumor |
72% | |