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. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: ACS Catal. 2016 Jan 25;6(3):1451–1454. doi: 10.1021/acscatal.5b02558

Scheme 2.

Scheme 2

Chemoenzymatic alkoxylation of thenalidine.a

aHal: as in Chart 1 using 0.05 equiv. 4-V. Pd: 0.005 equiv. [(allyl)PdCl]2, 0.015 equiv. RockPhos, 2 equiv. CF3CH2OH & Cs2CO3, PhMe, 90 °C, 14h.