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. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: ACS Catal. 2016 Jan 25;6(3):1451–1454. doi: 10.1021/acscatal.5b02558

Chart 1.

Chart 1

Boronic acid scope of chemoenzymatic arylation of tryptoline.a

aHal: 0.01 equiv. 3-SS, 0.0005 equiv. MBP-RebF, 9 U/mL GDH, 35 U/mL catalase, 20 equiv. NaBr, 40 equiv. glucose, 0.2 equiv. NAD & FAD, 3.5% v/v i-PrOH/phosphate buffer (25 mM, pH 8.0), 22 °C, 16h (See Figure S1). Pd: 0.05 equiv. Pd(OAc)2 & SPhos-SO3Na, 1.5 equiv. ArB(OH)2, 50% v/v i-PrOH/phosphate buffer (170 mM, pH 8.5), 90 °C, 1h.