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. 2016 Feb 14;7(8):8556–8579. doi: 10.18632/oncotarget.7388

Figure 2. (a) The GEN of young individuals and (b) the associated functional network.

Figure 2

(a) The upper left circle represents the TFs (68), the lower left circle represents the miRNAs (49), and the right circle represents the proteins (1035) for the GEN of young individuals. Links within the “proteins” circle represent PPIs, links between the “TFs” circle and the “proteins” circle represent regulation of TFs on target genes, and links between the “miRNAs” circle and the “proteins” circle represent regulation of miRNAs on target genes in the GEN of young individuals. (b) In the functional network of the GEN of young individuals, the first six enriched GO terms (biological processes) are regulation of transcription, regulation of RNA metabolic process, regulation of apoptosis, intracellular signaling cascade, regulation of transcription from RNA polymerase II promoter, and regulation of cell proliferation. The numbers in parentheses represents the number of proteins involved in each function.