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. 2016 Feb 14;7(8):8556–8579. doi: 10.18632/oncotarget.7388

Figure 3. a. The GEN of elderly individuals, and b. the associated functional network.

Figure 3

a. The upper left circle represents the TFs (127), the lower left circle represents the miRNAs (93), and the right circle represents the proteins (1481) for the GEN of elderly individuals. Links within the “proteins” circle represent PPIs, links between the “TFs” circle and the “proteins” circle represent regulation of TFs on target genes, and links between the “miRNAs” circle and the “proteins” circle represent regulation of miRNAs on target genes in the GEN of elderly individuals. b. In the functional network of the GEN of elderly individuals, the first six enriched GO terms (biological processes) are regulation of transcription, regulation of RNA metabolic process, regulation of apoptosis, intracellular signaling cascade, RNA processing, and regulation of cell proliferation. The numbers in parentheses represent the number of proteins involved in each function.