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. 2016 Feb 14;7(8):8556–8579. doi: 10.18632/oncotarget.7388

Figure 9. The specific core GEN of elderly individuals, as determined by the distinction between the core GEN of the young and elderly.

Figure 9

The upper left circle represents the TFs (20), the lower left circle represents the miRNAs (5), and the right circle represents the proteins (50) for the specific core GEN of elderly individuals. The red nodes represent DNA methylation of genes. Links within the “proteins” circle represent the significant PPIs, links between the “TFs” circle and the “proteins” circle represent significant regulation of TFs on target genes, and links between the “miRNAs” circle and the “proteins” circle represent significant regulation of miRNAs on target genes in the specific core GEN of elderly individuals.