Table 3. Core protein-coding genes regulated by core miRNAs in the specific core GEN of elderly individuals and the related pathways.

MiRNAs	Genes	Pathways
Let-7d	CDK4	p53 signaling pathway PI3K-Akt signaling pathway T cell receptor signaling pathway
Mir-223	FLNB	MAPK signaling pathway
Mir-130a	ZNF274	Neurotrophin signaling pathway

In the specific core GEN of elderly individuals, CDK4 is inhibited by let-7d, FLNB is inhibited by mir-223, and ZNF274 is inhibited by mir-130a. Moreover, CDK4 is involved in the p53 signaling pathway, PI3K-Akt signaling pathway, and T cell receptor signaling pathway. FLNB is involved in the MAPK signaling pathway, and ZNF274 is involved in Neurotrophin signaling pathway.