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. 2015 Dec 9;7(8):8590–8600. doi: 10.18632/oncotarget.6535

Figure 4. The p38 MAPK inhibitor reduced the Th17 cell response in the GITRL-treated CIA mice.

Figure 4

A. The frequency of Th17 cells in spleens from CIA mice with different treatments was analyzed by flow cytometry. The percentages of Th17 cells are indicated in representative dot plots.B. The total number (left) or percentages (right) of Th17 cells in spleens from three treatment groups are shown. C. The frequency of Th17 cells in draining lymph nodes from CIA mice with different treatments was analyzed by flow cytometry; percentages of Th17 cells are indicated in representative dot plots.D. The total number (left) and percentages (right) of Th17 cells in lymph nodes from three treatment groups were shown. E. The phosphorylation level of STAT3 Tyr705 and Ser727 in the spleen CD4+T cells of the mice from the different groups was detected by Western blot. The results indicated are in a representative photo.F., G. The phosphorylation level of STAT3 Tyr705 F. and Ser727 G. in the spleen CD4+T cells of the mice from the different groups. Data are mean±SD. *, P < 0.05.