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. 2015 Dec 9;7(8):8590–8600. doi: 10.18632/oncotarget.6535

Figure 5. P38 MAPK phosphorylation was upregulated in the CD4+T cells from RA patients.

Figure 5

A. PBMCs from 15 healthy controls and 18 patients were stained for phospho-p38 MAPK. The mean fluorescence intensity (MFI) of phosphor-p38 MAPK in CD4+T cells was compared between the RA patients and the healthy controls. All the values were gated on the CD3+CD4+ T cells.B. PBMCs from 15 healthy controls and 18 patients were stimulated for 5 hours with PMA/ionomycin and then stained for the cell surface molecule CD3 and CD8 as well as intracellular IL-17 and analyzed by flow cytometry. Percentages of Th17 cells were compared between RA patients and healthy controls.C. The correlation between the MFI of phospho-p38 MAPK in CD4+T cells and serum level of anti-CCP antibody in RA patients (r = 0.5545, p = 0.0169). Each data point represents an individual subject. *, P < 0.05; **, P < 0.01.