Figure 2. The disruption of circadian rhythms exists in the liver injury and fibrosis.

The livers undergo the variously chronic damages, such as alcohol, LPS, BDL, drug, CCl₄ and high fat, leading to the liver injury and fibrosis characterized by the activation of HSCs and the hepatocytes injury, apoptosis or death. Particularly, it could disrupt the circadian rhythm in livers through causing misalignment of the amplitude and phase of a normal rhythm in key cell types, such as HSCs and hepatocytes.