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. 2016 Jan 28;7(8):8625–8639. doi: 10.18632/oncotarget.7065

Table 2. Characteristics of various circadian genes involved in hepatocellular carcinoma.

Genes Expression Function and regulatory mechanisms References
Bmal1 Influence cell cycle [149]
Bmal2 Inhibition of cell proliferation and cell cycle; Induction of apoptosis [144]
Clock HULC [151]
Per1 Methylation, HULC [146, 149, 151]
Per2 Counteract HCV replication; tumor size(>3 cm) [146, 147, 149]
Per3 Overexpression of EZH2, tumor size(>3 cm) [146, 149]
Cry1 Induction of cell apoposis, Methylation [148, 151]
Cry2 Induction of cell apoposis [146, 148]
CKIε EZH2 [149]
Tim tumor grade [149]