Table 2. Characteristics of various circadian genes involved in hepatocellular carcinoma.

Genes	Expression	Function and regulatory mechanisms	References
Bmal1	↓	Influence cell cycle	[149]
Bmal2	↓	Inhibition of cell proliferation and cell cycle; Induction of apoptosis	[144]
Clock	↓	HULC	[151]
Per1	↓	Methylation, HULC	[146, 149, 151]
Per2	↓	Counteract HCV replication; tumor size(>3 cm)	[146, 147, 149]
Per3	↓	Overexpression of EZH2, tumor size(>3 cm)	[146, 149]
Cry1	↓	Induction of cell apoposis, Methylation	[148, 151]
Cry2	↓	Induction of cell apoposis	[146, 148]
CKIε	↓	EZH2	[149]
Tim	↓	tumor grade	[149]