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. 2016 Jan 30;7(8):8640–8652. doi: 10.18632/oncotarget.7082

Figure 2. Effects of six gastric mucosal protectants on AP-1, NF-κB, NRF2, p53 and STAT3 transcriptional activation in Caco-2 cells.

Figure 2

Irsogladine maleate A. rebamipide B. troxipide C. ecabet sodium hydrate D. sofalcone E. and teprenone F. After transient transfection of the indicated reporter plasmid for 24 h, Caco-2 cells were treated with 200 μM of the test reagent for 24 h (closed box), or for 24 h without the test reagent (open box). The basal luciferase activity of NF-κB in the control was set as 1.0. A larger magnification of AP-1 transcriptional activity in Figure 2A is inserted within the square. The data are the means ± SD (n = 3), ***p < 0.001, **p < 0.01, *p < 0.05 vs control. NgCT: negative control.