Table 2. The levels of RCs detected in liver samples of irsogladine maleate-treated or non-treated Min mice.
| Compounds | Irsogladine maleate (ppm) | ||
|---|---|---|---|
| 0 | 5 | 50 | |
| pmol/g wet tissue | |||
| Acetaldehyde | 14242.2 ± 8478.3 | 4051.3 ± 4231.2** | 9757.4 ± 8245.2 |
| Acrolein | 1239.5 ± 144.6 | 968.4 ± 303.1** | 932.3 ± 211.9** |
| Glyoxal | 8440.8 ± 3058.1 | 9864.9 ± 3368.4 | 6465.5 ± 3025.6 |
| Propanal | 1509.7 ± 534.4 | 1341.8 ± 369.4 | 1454.4 ± 431.8 |
| Crotonaldehyde | 5.4 ± 9.9 | 15.2 ± 19.8 | 22.8 ± 18.7* |
| Butanal | 1205.2 ± 589.2 | 998.7 ± 356.6 | 1377.9 ± 409.7 |
| Pentanal | 31.4 ± 18.9 | 17.6 ± 12.3* | 12.8 ± 17.4** |
| 2-Hexenal | 73.7 ± 14.2 | 68.1 ± 15.0 | 61.5 ± 9.9** |
| Hexanal | 4388.3 ± 735.4 | 3726.9 ± 593.2* | 3665.3 ± 531.9* |
| 2-Heptenal | 5.3 ± 9.1 | 3.1 ± 7.1 | 0.6 ± 1.3 |
| Heptanal | 651.2 ± 117.9 | 612.2 ± 89.6 | 627.5 ± 94.0 |
| 2-Octenal | 14.7 ± 4.3 | 13.7 ± 3.3 | 12.6 ± 2.3 |
| Octanal | 1956.9 ± 466.0 | 1858.5 ± 292.3 | 2111.7 ± 335.1 |
| 2,4-NDE | 147.9 ± 22.9 | 124.3 ± 17.6* | 120.0 ± 15.3** |
| 2-Nonenal | 685.2 ± 100.7 | 565.5 ± 42.9** | 502.9 ± 44.4*** |
| Nonanal | 5656.4 ± 2082.8 | 4800.1 ± 989.3 | 6214.0 ± 1546.3 |
| 2,4-DDE | 53.5 ± 38.2 | 46.5 ± 36.8 | 35.0 ± 22.6 |
| HNE | 230.0 ± 34.2 | 186.7 ± 31.4** | 181.9 ± 27.0** |
| Decanal | 1728.3 ± 750.0 | 1192.5 ± 600.1* | 2027.2 ± 269.8 |
| EDE | 174.3 ± 159.8 | 178.4 ± 131.0 | 207.7 ± 174.2 |
| 2-Undecenal | 47.0 ± 8.1 | 43.7 ± 7.1 | 47.0 ± 8.3 |
| Undecanal | 761.0 ± 190.4 | 599.8 ± 154.7* | 790.9 ± 119.4 |
| Dodecanal | 1337.7 ± 355.8 | 769.6 ± 456.9** | 1147.1 ± 336.7 |
| Tridecanal | 1163.6 ± 330.2 | 673.8 ± 372.6** | 952.4 ± 323.1 |
| Tetradecanal | 1250.9 ± 521.3 | 699.6 ± 154.0** | 740.9 ± 207.6* |
| Pentadecanal | 3437.1 ± 1311.8 | 2469.2 ± 857.4 | 3276.6 ± 1056.0 |
| Hexadecanal | 4141.7 ± 737.2 | 3442.5 ± 535.6* | 3533.3 ± 595.1* |
| 8,11,14-HpDTE | 145.2 ± 69.2 | 123.0 ± 79.2 | 160.0 ± 124.7 |
| 8,11-HpDDE | 113.0 ± 34.3 | 98.9 ± 24.5 | 104.1 ± 42.7 |
| 8-HpDE | 215.8 ± 59.9 | 163.5 ± 31.8* | 166.9 ± 60.9 |
| Heptadecanal | 877.7 ± 406.6 | 460.9 ± 129.2** | 573.6 ± 207.2* |
| Octadecanal | 616.5 ± 335.1 | 189.8 ± 157.0** | 455.7 ± 226.7 |
Data are presented as the means ± SD (n = 10).
Significantly different from the untreated control group at
*
p < 0.05
**
p < 0.01
***
p < 0.001.
RCs: reactive carbonyl species.