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. 2016 Jan 30;7(8):8688–8699. doi: 10.18632/oncotarget.7086

Figure 1. Dose-dependent inhibition of NAT1 activity by the aralkyl isothiocyanates benzyl isothiocyanate (BITC) and phenetyl isothiocyanate (PEITC).

Figure 1

(A) Chemical structures of the ITCs (BITC and PEITC) and N-methylphenethylamine (NMPEA), a non-ITC analog of PEITC. (B and C) Effect of BITC, PEITC and NMPEA on NAT1 activity. NAT1 enzyme (1 μM) was incubated with increasing concentrations of BITC, PEITC and NMEPA for 30 min at 37°C. Residual NAT1 N-acetylation (B) and O-acetylation activities (C) were measured using p-aminobenzoic acid (pABA) and N-hydroxy-4-aminobiphenyl (N-OH-4-ABP) as AA substrates, respectively. Error bars indicate S.D. values. Results are presented as percent control NAT1 activity.