. 2016 Jan 3;7(8):8823–8838. doi: 10.18632/oncotarget.6815

Table 3. Univariate and multivariate Cox regression analyses of COL3A1 mRNA expression and clinical variables for overall and disease-free survival of CRC patients^a.

Survival	Methods	Variables	β^b	SE (β)^c	Wald χ2	p	Hazard ratio	95% CI^d
Survival	Methods	Variables	β^b	SE (β)^c	Wald χ2	p	Hazard ratio	Low	Upper
Overall-survival
	Univariate Cox regression
		Age	0.006	0.009	0.472	0.492	1.006	0.988	1.025
		COL3A1	0.720	0.247	8.517	0.004	2.055	1.267	3.333
		Grade	0.695	0.241	8.311	0.004	2.004	1.249	3.215
		Recurrence	1.569	0.308	25.958	0.000	4.801	2.625	8.778
		Sex	0.100	0.237	0.176	0.675	1.105	0.694	1.759
		Stage	1.049	0.154	46.482	0.000	2.854	2.111	3.859
	Multivariate Cox regression
		Recurrence	1.407	0.315	20.010	0.000	4.084	2.205	7.565
		Stage	0.441	0.207	4.531	0.033	1.554	1.036	2.333
Disease-Free survival
	Univariate Cox regression
		Age	0.003	0.008	0.116	0.733	1.003	0.986	1.020
		COL3A1	0.500	0.226	4.903	0.027	1.648	1.059	2.565
		Grade	0.692	0.230	9.062	0.003	1.997	1.273	3.133
		Recurrence	2.272	0.293	60.110	0.000	9.703	5.463	17.235
		Sex	0.051	0.222	0.052	0.819	1.052	0.681	1.626
		Stage	0.985	0.141	48.820	0.000	2.677	2.031	3.528
	Multivariate Cox regression
		Recurrence	2.113	0.299	49.839	0.000	8.276	4.603	14.882
		Stage	0.429	0.197	4.742	0.029	1.536	1.044	2.259

The analysis was performed using the Smith Colorectal dataset from the Oncomine cancer gene expression microarray DB (https://www.oncomine.org/resource/login.html).

β, regression coefficient.

SE, standard error.

CI, confidence interval.

Table 3. Univariate and multivariate Cox regression analyses of COL3A1 mRNA expression and clinical variables for overall and disease-free survival of CRC patientsa.