Table 4. Univariate and multivariate Cox regression analyses of COL3A1 protein expression in cancer epithelial cells and clinical variables for overall survival of CRC patients.

Methods	Variables	βa	SE (β)b	Wald χ2	p	Hazard ratio	95% CIc
							Low	Upper
Univariate Cox regression
	Age	0.010	0.011	0.910	0.340	1.010	0.989	1.032
	Gender	−0.323	0.289	1.245	0.264	0.724	0.411	1.276
	COL3A1 (epithelial)	0.719	0.332	4.697	0.030	2.053	1.071	3.935
	Grade	0.223	0.150	2.228	0.136	1.250	0.932	1.677
	T	0.636	0.207	9.442	0.002	1.889	1.259	2.834
	N	0.428	0.098	19.094	0.000	1.534	1.266	1.859
	M	2.350	0.626	14.099	0.000	10.484	3.075	35.747
	Stage	0.271	0.068	15.794	0.000	1.311	1.147	1.499
	Metastasis	2.315	0.757	9.341	0.002	10.123	2.294	44.664
	COL3A1 (stromal)	0.128	0.302	0.181	0.671	1.137	0.629	2.055
	Tumor volume	0.000	0.000	2.002	0.157	1.000	1.000	1.001
Multivariate Cox regression
	T	0.776	0.244	10.124	0.001	2.173	1.347	3.506
	N	0.426	0.111	14.815	0.000	1.532	1.233	1.903
	M	3.612	1.038	12.101	0.001	37.056	4.841	283.663

^aβ, regression coefficient.

^bSE, standard error.

^cCI, confidence interval.