Figure 4. Bufalin sensitized cervical cancer cells to paclitaxel treatment.

A. The concurrent administration of cells with Bufalin and paclitaxel for 48 h results in synergistic inhibitory effect on the growth of Siha and Hela cells. B, Representative images and number of colonies formed by Siha and Hela cells treated with Bufalin or paclitaxel alone, and Bufalin plus paclitaxel. The experiments were repeated three times, and a representative experiment is shown. C, Western blot analysis showing that combination of RY-2f and cisplatin inhibited the lower expression of integrin α2, integrin β4, FAK and GSK3β than each agent alone.