Table 2. Results of multivariate Cox regression.
| Gene | Adjusted HR$ | 95% C.I. | P value | |
|---|---|---|---|---|
| All patients (n = 261) | ||||
| EGFR | 1.89 | 1.16 | 3.10 | 0.011 |
| ERBB2 | 1.68 | 1.03 | 2.74 | 0.038 |
| ERBB3 | 1.65 | 1.02 | 2.68 | 0.042 |
| ERBB4 | 1.62 | 1.01 | 2.61 | 0.047 |
| Wild type (n = 118) | ||||
| EGFR | 1.13 | 0.58 | 2.22 | 0.718 |
| ERBB2 | 1.84 | 0.96 | 3.55 | 0.068 |
| ERBB3 | 0.94 | 0.51 | 1.73 | 0.841 |
| ERBB4 | 1.23 | 0.64 | 2.37 | 0.527 |
| EGFR-activating mutations (n = 143) | ||||
| EGFR | 3.53 | 1.58 | 7.87 | 0.002 |
| ERBB2 | 2.00 | 0.91 | 4.40 | 0.086 |
| ERBB3 | 2.64 | 1.17 | 5.95 | 0.019 |
| ERBB4 | 3.40 | 1.55 | 7.48 | 0.002 |
| L858R (n = 70) | ||||
| EGFR | 2.96 | 1.02 | 8.57 | 0.046 |
| ERBB2 | 2.86 | 0.91 | 9.03 | 0.074 |
| ERBB3 | 3.98 | 1.02 | 15.63 | 0.047 |
| ERBB4 | 7.22 | 2.23 | 23.36 | 0.001 |
| Exon 19 deletion (n = 73) | ||||
| EGFR | 7.25 | 1.74 | 30.27 | 0.007 |
| ERBB2 | 2.47 | 0.64 | 9.60 | 0.192 |
| ERBB3 | 3.39 | 0.88 | 13.03 | 0.076 |
| ERBB4 | 1.88 | 0.53 | 6.71 | 0.332 |
$
Hazard ratio
+ EGFR-activating mutations include L858R and exon-19-deletion
The association between members of ErbB family DNA copy number abundance and overall survival was evaluated by multivariate Cox hazard regression in all 261 patients, 118 wild type patients, 70 EGFR L858R patients, 73 EGFR exon-19-deletion patients, and all 143 EGFR-activating mutation patients. Potential confounding factors such age, gender, stage, and cell type were adjusted. Hazard ratio, confidence interval, and p-value were shown.