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. 2016 Jan 27;7(8):9026–9040. doi: 10.18632/oncotarget.7030

Figure 6. PN induces senescence in melanoma cells expressing MITF-M at high level.

Figure 6

PN was used at indicated concentrations. A, B. Senescence shown as (A) enlargement of cells (FSC) and increase in cell granularity (SSC) after 22 hours of treatment with PN and (B) changes in senescence-associated β-galactosidase (SA-β-gal) activity evaluated under the phase-contrast microscope (scale bar = 50 μm) and quantified (right). C. Basal levels of MCL-1 protein in melanoma cell populations analyzed by immunoblotting. Equal loading was confirmed by β-actin.