Table 4. Multivariate Analysis (Cox regression) on the Overall Survival and Disease-free Survival.

Variables	Overall Survival				Disease-free Survival
		95% CI				95% CI
	RR	Lower	Upper	P	RR	Lower	Upper	P
Age†	2.228	1.598	3.106	<0.001*	1.344	1.016	1.779	0.038*
WBC§	2.192	1.539	3.123	<0.001*	1.731	1.285	2.331	<0.001*
KaryotypeΨ	2.227	1.230	4.032	0.008*	1.792	1.087	2.955	0.022*
NPM1/FLT3-ITDζ	0.343	0.171	0.686	0.002*	0.304	0.163	0.567	<0.001*
CEBPA‡	0.462	0.238	0.896	0.022*	0.630	0.392	1.014	0.057
RUNX1	1.942	1.129	3.339	0.016*	1.788	1.138	2.809	0.012*
WT1	2.560	1.508	4.346	<0.001*	2.469	1.614	3.778	<0.001*
ASXL1	1.126	0.622	2.039	0.695	0.978	0.562	1.704	0.938
IDH2**	0.539	0.284	1.020	0.058	0.840	0.530	1.333	0.459
DNMT3A	1.919	1.166	3.158	0.010*	2.130	1.400	3.241	<0.001*
TP53	3.613	1.598	8.167	0.002*	2.824	1.372	5.812	0.005*
SF	2.243	1.380	3.647	0.001*	2.136	1.376	3.314	0.001*

Abbreviation: RR, relative risk; CI, confidence interval, SF, splicing factor.

^*Statistically significant (P < 0.05)

^†Age > 50 relative to Age ≤50 (the reference)

^§WBC greater than 50,000/μL vs. 50,000/μL or less

^ζNPM1^mut/FLT3-ITD^neg vs. other subtypes

^‡CEBPA^{double-mutation} vs. others

^Ψunfavorable cytogenetics vs. others

^**IDH2 mutations included R140 and R172 mutations