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. 2016 Jan 25;7(8):9388–9403. doi: 10.18632/oncotarget.7011

Figure 3. PPD12 inhibits the activity of ABCB1 in MDR cells.

Figure 3

(A) PPD12 enhances ABCB1 activity in vitro with EC50= 1.52 μM. (B) PPD12 decreases the efflux of ADM in KB/VCR cells, but not in KB cells. (C) PPD12 increases the concentration of ABCB1-substrates Adriamycin (ADM) and Rhodamine123 (Rho) in the KB/VCR cells. (D) PPD12 elevates the concentration of ABCB1-substrates in the MDR KB/VCR and MCF-7/ADM cells, but not their parental KB and MCF-7 cells. (E) 5 μM PPD12 suppresses the efflux of ADM in a time- and dose-dependent manner in KB/VCR and MCF-7/ADM cells.