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. 2016 Jan 25;7(8):9448–9461. doi: 10.18632/oncotarget.7021

Figure 2. HBV carrying LFCD mutation promoted cell growth in vitro and in vivo .

Figure 2

A and B. Cell proliferation rates assessed by MTT assays for Huh7-neo, -pol, and -HBV cells (A), and for HepG2-neo, -pol, and -HBV cells (B). “**”, P < 0.01. C. Anchorage independent growth of Huh7 and HepG2 derived stable cell lines in soft agar. Quantitative assessment of the colony numbers for Huh7 (lower left) and HepG2 (lower right) derived stable cell lines. Values were given in mean ± SD from triplicate experiments. “*”, P < 0.05; “**”, P < 0.01. D. Comparison of tumorigenicity in nude mice for Huh7 (upper panel) and HepG2 (lower panel) derived stable transformants. Huh7-neo and HepG2-neo cells were subcutaneously injected into the left side of backs, while Huh7-pol and HepG2-pol cells were injected into the right side of backs for comparison.