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. 2016 Jan 29;7(8):9513–9524. doi: 10.18632/oncotarget.7069

Figure 8. Co-overexpression of YAP and P73 promotes TRAIL-induced apoptosis.

Figure 8

Wild-type H460 and A549 cells were treated with 20 ng/mL TRAIL for 6 h or 200 ng/mL for 24 h, respectively, after transient transfection with the indicated plasmids. The percentage of apoptosis was measured using PE/7-AAD staining and was analyzed by flow cytometry (A). The histograms demonstrate the apoptotic rates of the cells, and the results represent the means of at least three independent experiments (B). The expression of YAP, p73 and DR5 was detected by western blotting (C). β-Actin was used as an internal control to ensure equal protein loading.