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. 2016 Feb 11;7(9):9620–9633. doi: 10.18632/oncotarget.7330

Figure 4. Loss of Raptor but not Rictor in cones accelerates cone death.

Figure 4

A.-H. Analyses of MCre+ and MCre- littermates harboring the Raptorfl/fl alleles (A-D) and the Rictorfl/fl alleles (E-H) at 4 weeks post sodium iodate injection. A., E. Representative retinal flat-mounts showing lower cone density in MCre+ animals with the Raptor conditional allele. Orientation in (A, E) is the same as shown in Figure 2A. B., F. Percentage colocalization between cone arrestin and surface area indicated. Upon loss of Raptor there is a statistically significant drop in cones. C., G. Average of RPE damage radius. D., H. ONL thickness diagram depicting rod survival. There is no difference in RPE damage and ONL thickness between MCre+ and MCre- animals. Scale bars in (A, E): 1mm (upper) and 200 μm (lower). (n: number of animals analyzed; ns: not significant; *: p < 0.05); **: p < 0.01).