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. 2016 Jan 19;7(9):9732–9741. doi: 10.18632/oncotarget.6947

Figure 2. More effective radiosensitization by PARPi in HR-deficient compared to HR-proficient HNSCCs.

Figure 2

(A and B) No difference in cell survival after irradiation or PARPi (1 μM for 2 h) alone in HR-proficient and HR-deficient HNSCCs. (C and S1C) Successful inhibition of PAR formation after PARPi in HNSCCs. (D and S1D, E) Stronger radiosensitization by PARPi in cell lines deficient in HR with higher enhancement ratios (p = 0.05). Statistical analysis of at least three different experiments was performed using Student's t-test.