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. 2016 Jan 19;7(9):9732–9741. doi: 10.18632/oncotarget.6947

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Copyright: © 2016 Wurster et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) HNSCC cells were treated as indicated and 1st metaphases after treatment were analyzed. (B) Examples of chromosome preparations show more radial chromosomes (black arrows) in HR-deficient cells after combined treatment of PARPi and irradiation. (C) Increase in the percentage of cells with radial chromosomes after PARPi, irradiation and combined treatment in ten HNSCCs. For every cell line analyzed radials were plotted after PARPi, irradiation and combined treatment; untreated controls were subtracted. (D) A significantly higher percentage of radial chromosomes after combined treatment was observable in the HR-deficient compared to HR-proficient HNSCCs (p = 0.003). Statistical analysis of at least three different experiments was performed using Student's t-test.