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. 2016 Feb 2;7(9):9788–9800. doi: 10.18632/oncotarget.7125

Figure 2. CagA induces MGMT gene hypermethylation and its expression loss.

Figure 2

(A and B) MGMT methylation status in CagA+ SGC-7901 and HP-infected cells. Increased MGMT methylation is observed in CagA transfected and CagA+ HP infected cells compared with control groups. (C and D) MGMT expression in CagA stablely transfected and HP cocultured (MOI 100:1) cells detected by WB. MGMT downregulation is observed in CagA stablely transfected and CagA+ HP infected cells compared with control groups. The graph represents densitometric analysis of the bands obtained for each signal. Results are expressed as relative expression compared with control cells (*p < 0.05). Each value is the mean ± SD of three experiments.