Table 1. Relationship between MGMT expression, MGMT gene methylation, DNMT1 expression and clinicopathologic parameters in GC.
| Clinicopathologic Parameters (n = 33) |
MGMT-MPS (++/±)n |
P |
MGMT-IHC (++/±)n |
P |
DNMT1-IHC (++/±)n |
P |
|---|---|---|---|---|---|---|
| HP (CagA) | ||||||
| Positive | 17/5 | 0.009 | 7/15 | 0.031 | 18/4 | 0.049 |
| Negative | 3/8 | 8/3 | 5/6 | |||
| Age (years) | ||||||
| ≤ 59 | 10/5 | N | 7/8 | N | 12/3 | N |
| > 59 | 10/8 | 8/10 | 11/7 | |||
| Gender | ||||||
| Male | 12/8 | N | 9/11 | N | 13/7 | N |
| Female | 8/5 | 6/7 | 10/3 | |||
| Bormann Type | ||||||
| I–II | 4/3 | N | 4/3 | N | 6/1 | N |
| III–IV | 16/10 | 11/15 | 17/9 | |||
| Location | ||||||
| Middle/Proximal | 7/5 | N | 5/7 | N | 8/4 | N |
| Distal | 13/8 | 10/11 | 15/6 | |||
| Diameter (cm) | ||||||
| ≤ 5 | 11/8 | N | 9/10 | N | 13/6 | N |
| > 5 | 9/5 | 6/8 | 10/4 | |||
| Histologic type | ||||||
| Intestinal | 8/5 | N | 5/8 | N | 9/4 | N |
| Diffuse | 12/8 | 10/10 | 14/6 | |||
| Depth of invasion | ||||||
| T1, T2 | 6/4 | N | 4/6 | N | 8/2 | N |
| T3, T4 | 14/9 | 11/12 | 15/8 | |||
| Lymph-node metastasis | ||||||
| No | 7/4 | N | 5/6 | N | 8/3 | N |
| Yes | 13/9 | 10/12 | 15/7 | |||
| Differentiation | ||||||
| High/Middle | 8/4 | N | 5/7 | N | 8/4 | N |
| Moderate/Low | 12/9 | 9/12 | 15/6 | |||
| TNM stage | ||||||
| I–II | 1/9 | 0.000 | 8/2 | 0.020 | 5/5 | N |
| III–IV | 19/4 | 7/16 | 18/5 | |||
Abbreviation: N, no significant difference.
Statistical significance is assessed using the Pearson χ2 test, Fisher's exact test, or the Mann-Whitney U test. Differences are considered statistically significant in a two-tailed test for p < 0.05.