Skip to main content
. 2016 Feb 2;7(9):9951–9963. doi: 10.18632/oncotarget.7127

Figure 3. Hierarchical clustering of the MDS patient samples and miRNAs.

Figure 3

Each row represents a miRNA and each column represents a patient sample. Green indicates low expression relative to the mean expression level of the samples and red indicates high expression. The mutational status of each sample is indicated at the top. The miRNA class of each miRNA as well as differentially expressed miRNAs between wild-type MDS samples and SF3B1 mutated samples are indicated to the left. It is observed that 14 out of 17 samples containing a spliceosome mutation within SF3B1 or SRSF2 clustered together. Most of the miRNAs, which were differentially expressed between wild-type MDS samples and samples containing an SF3B1 mutation clustered together. Finally, all mirtrons except miR-4742-5p were found within the same cluster.