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. 2016 Jan 28;7(9):10037–10050. doi: 10.18632/oncotarget.7048

Figure 2. CUL4A promotes GC cell proliferation.

Figure 2

A. MTT assay results after knocking down or overexpressing CUL4A. Knocking down CUL4A inhibited cell proliferation of HGC-27 cells compared to cells in the control mock-treated group; whereas, overexpressing CUL4A enhanced MGC-803 cell proliferation. B. Clone formation assay results after knocking down or overexpressing CUL4A. Knocking down CUL4A suppressed SGC-7901 and HGC-27 cell proliferation in clone formation assays; whereas, MGC-803 cell proliferation was enhanced by overexpressing CUL4A. C. Knocking down CUL4A resulted in the upregulation of p21 and p27 in SGC-7901 cells; whereas, overexpressing CUL4A led to opposite results in MGC-803 cells. D. Representative images of tumors from mice in each group. Tumor volumes were measured on the indicated days. Each bar represents the mean±SD of three independent experiments. *p-value <0.05.