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. 2016 Jan 28;7(9):10037–10050. doi: 10.18632/oncotarget.7048

Figure 6. miR-9 and miR-137 regulate the CUL4A-LATS-Hippo signaling pathway.

Figure 6

A. Mature miR-9 and miR-137 levels were measured byqPCR after transfecting with miRNA mimics. B. CCK-8 assay results of HGC-27 cells after transfecting with miR-9 and miR-137 mimics. C. miR-9 and miR-137 inhibited HGC-27 cell invasion in Transwell chamber assays. D. Western blotting results ofthe levels of proteins in CUL4A-LATS1-Hippo signaling pathway in HGC-27 cells after transfecting with CUL4A-siR-1, miR-9 or miR-137, respectively. E. Immunofluorescence results of YAP in GC cells transfected with miR-9 and miR-137 mimics. F. Levels of mRNA for the indicated genes in the Hippo signaling pathway were decreased by miR-9 and miR-137 in HGC-27 cells. Each bar represents the mean±SD of three independent experiments. *p-value <0.05, **p-value <0.01.