Figure 2. SERPINB1 gene expression is upregulated in melanoma cell lines derived from clinical responders to chemotherapy as compared to cell lines derived from non-responders.

The heat map for SERPINB1 gene expression shows up-regulated gene expression in red, down-regulated gene expression in green. Cell lines were established from metastatic lesions of six melanoma patients biopsied for chemosensitivity testing and analyzed by gene expression profiling using the Affymetrix microarray technology. The best chemosensitivity indices reflect the results of in vitro chemosensitivity testing of tumor tissue biospy material also used for the establishment of the cell lines analyzed. The sensivity-directed chemotherapy regimen applied to the corresponding patients after in vitro testing as well as its' clinical best response is provided. PR, partial response; PD, progressive disease.