Table 2. Summary of chromosomal rearrangements by whole genome sequencing analysis in LM200-#25.
ID | Break 1 Chromosome | Break 1 Position | Break 2 Chromosome | Break 2 Position | Rearrangement Type | Sequence in Between Breakpoints |
---|---|---|---|---|---|---|
23 | 2 | 15,742,392 | 2 | 16,708,640 | RF | CTGAA insertion |
29 | 2 | 48,937,454 | 2 | 81,807,507 | RF | C microhomology |
30 | 2 | 53,106,380 | 2 | 53,252,037 | LD | AA microhomology |
50 | 3 | 144,705,944 | 12 | 28,795,184 | CT | TT microhomology |
76 | 5 | 6,330,710 | 5 | 6,378,473 | RF | TG microhomology |
80 | 5 | 19,854,137 | 5 | 89,613,562 | LD | |
91 | 5 | 89,613,939 | 20 | 14,453,942 | CT | TGGA microhomology |
93 | 5 | 95,994,652 | 5 | 96,157,380 | RF | GAT microhomology |
108 | 7 | 26,274,055 | 7 | 123,601,513 | LD | |
109 | 7 | 51,228,098 | 7 | 51,281,802 | RF | TT microhomology |
119 | 7 | 127,757,875 | 7 | 127,820,864 | FF | TTT microhomology |
120 | 7 | 127,757,880 | 11 | 23,404,604 | CT | |
143 | 12 | 53,845,481 | 20 | 5,707,700 | CT | G microhomology |
167 | 20 | 57,562,329 | 20 | 57,708,236 | LD | GCTCTGGTCCTGCATGACGTCCGTAGGATCACTT insertion |
*Bold numbers indicate that several breakpoints were located in close proximity
chromosomal translocation
long deletion
forward and forward
reverse and forward