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. 2016 Feb 3;7(9):10228–10242. doi: 10.18632/oncotarget.7169

Figure 9. Effects of NMU knockdown on tumor growth and animal survival rate in vivo.

Figure 9

(A) Control RL95-2 and NMU-knockdown RL95-2 cells were subcutaneously injected into nude mice and the sizes of the tumors formed at indicated intervals were measured. (B) The weights of harvested tumors at the end of experiments were measured. The results are shown as the mean ± SEM. *p < 0.05. Scale bar, 1 cm. (C) Immunohistochemical analyses against vimentin, CD44, Ki-67 and cleaved caspase 3 were performed. Cell morphology was revealed by counter-staining with hematoxylin. Scale bars, 100 μm. (D) Control RL95-2 and NMU-knockdown RL95-2 were intraperitoneally injected into nude mice and the survival rates of the mice at indicated intervals were monitored (n = 10).