Table 2. Effects of sodium alginate on incidence and multiplicity of hepatic neoplasms and pre-neoplastic lesions in the experimental mice.
| Group no. | Treatment | No. of mice | Incidence | Multiplicitya | ||||
|---|---|---|---|---|---|---|---|---|
| FCAb | Adenoma | HCCc | FCA | Adenoma | HCC | |||
| G1 | DEN | 12 | 10/10 (100%) | 8/10 (80%) | 5/10 (50%) | 5.3 ± 3.4d | 2.0 ± 2.2 | 1.1 ± 1.6 |
| G2 | DEN/High-molecular SA | 12 | 10/10 (100%) | 1/10e (10%) | 1/10 (10%) | 3.0 ± 2.5 | 0.1 ± 0.3f | 0.3 ± 0.9 |
| G3 | DEN/Low-molecular SA | 12 | 8/9 (88.8%) | 1/9 (11.1%) | 0/9e (0%) | 1.4 ± 1.0f | 0.1 ± 0.3f | 0 |
a
Number of neoplasms per mouse.
b
FCA, foci of cellular alteration.
c
HCC, hepatocellular carcinoma.
d
Mean ± SD.
e
Significantly different from group 1 by Fisher's exact probability test (P < 0.05).
f
Significantly different from group 1 by Tukey-Kramer Multiple Comparison Test (P < 0.05).