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. 2016 Jan 25;7(9):10513–10521. doi: 10.18632/oncotarget.7013

Table 3. GO process, KEGG Pathway, Panther pathway and REACTOME Pathway enriched by meta-signature miRNA targets.

Pathway enrichment analysis P-value Targets
GO process
GO:0010468:regulation of gene expression 3.32262E-11 182
GO:0060255:regulation of macromolecule metabolic process 6.26409E-11 200
GO:0010556:regulation of macromolecule biosynthetic process 1.02846E-10 179
GO:0019222:regulation of metabolic process 2.92559E-10 214
GO:0031323:regulation of cellular metabolic process 8.60126E-10 205
GO:0080090:regulation of primary metabolic process 8.88383E-10 197
GO:0009889:regulation of biosynthetic process 1.49881E-9 181
GO:0031326:regulation of cellular biosynthetic process 2.81697E-9 179
GO:0010608:posttranscriptional regulation of gene expression 7.88979E-9 30
GO:0044260:cellular macromolecule metabolic process 7.53946E-8 273
KEGG Pathway
04510:Focal adhesion 2.40574E-5 22
04512:ECM-receptor interaction 7.55414E-5 13
05200:Pathways in cancer 1.20000E-4 28
05214:Glioma 6.07598E-4 10
05210:Colorectal cancer 1.31904E-3 11
05222:Small cell lung cancer 4.70774E-3 10
05212:Pancreatic cancer 6.08526E-3 9
00310:Lysine degradation 6.31374E-3 7
05215:Prostate cancer 6.89094E-3 10
04520:Adherens junction 9.08516E-3 9
Panther Pathways
P00034:Integrin signalling pathway 8.30518E-4 22
P04398:p53 pathway feedback loops 6.41257E-3 7
P00030:Hypoxia response via HIF activation 7.53552E-3 5
REACTOME Pathway
REACT_16888:Signaling by PDGF 5.61551E-7 14
REACT_18266:Axon guidance 1.17314E-5 11
REACT_13552:Integrin cell surface interactions 2.21768E-4 12
REACT_498:Signaling by Insulin receptor 3.34885E-3 7