Figure 6. Administration of Trast-NG/DOX reduces the cell proliferation and promotes the apoptosis in BT-474 xenograft tumors and its activity is enhanced by 17AAG.

Post-treatment tumor sections were stained for Ki-67 and caspase-3 and % Ki-67-positive A. and % caspase-3-positive B. cells were calculated based on enumeration of at least 1000 cells. Tumors from three mice per group were analyzed. Data are presented as mean ± SD (n = 5 random microscopic fields for each tumor). The treatment groups are indicated.