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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Macromol Biosci. 2015 Aug 10;16(1):63–73. doi: 10.1002/mabi.201500220

Table 1.

Composition of PR+: The threading efficiency was calculated based on a presumed 1:2 HPCD:PO unit ratio. # CD refers to the number of HPCD molecules threaded onto the Pluronic core and DMEDA represents umber of DMEDA attached to each PR+ as determined by 1H NMR integration. * Molecular weight estimated from proton NMR integration.

PR+ # CD DMEDA DMEDA/CD HLBa Threading Efficiencyb Mw of PR+ (kDa)c
F127 15 63 4.2 22 46% 42.9
L81 11 95 8.6 2 52% 32.4
L64 8 71 8.8 15 53% 23.9
F68 3 10 3.3 29 22% 19.5
L35 3 20 6.6 19 37% 11.3
a

HLB (hydrophilic-lipophilic balance) of the copolymers were determined by the manufacturer.

b

The threading efficiency was calculated based on a presumed 1:2 HPCD:PO unit ratio. # CD refers to the number of HPCD molecules threaded onto the Pluronic core and DMEDA represents umber of DMEDA attached to each PR+ as determined by 1H NMR integration.

c

Molecular weight estimated from proton NMR integration.