Skip to main content
. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: Pharm Res. 2015 Feb 19;32(8):2516–2526. doi: 10.1007/s11095-015-1640-3

Table I.

Digoxin (0.01 µM) Transport in MDCK-MDR1 and Caco-2 Cells in the Presence of GG918 (0.5 µM)

MDR1-MDCK cells Caco-2 cells
Digoxin +GG918 Digoxin +GG918
Papp A->B (×10−6 cm/s) (±SD) 0.26±0.02 0.41±0.10 0.64±0.03 1.17±0.07
Papp B->A (×10−6 cm/s) (±SD) 2.00±0.01 0.67±0.06 1.64±0.13 1.19±0.05
Efflux Ratio 6.75±1.34 1.52±0.16 2.57±0.33 1. 14±0.13