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. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: Neuron. 2012 Dec 6;76(5):871–885. doi: 10.1016/j.neuron.2012.11.020

Figure 6. ApoE Fragmentation Pattern in Human Temporal Cortex in Non-Demented Controls and in Age-Matched AD Patients.

Figure 6

Compared with full-length apoE (34 kDa), proteolytic cleavage generates an initial fragment with a molecular weight of ~29 kDa. Subsequent to this, fragments of ~12–20 kDa are generated. In AD patients, there is an apoE4 gene–dose effect on apoE fragmentation, whereby apoE4/3 subjects have more fragments than apoE3/3 subjects and the apoE4/4 subjects have the greatest amount of fragments.