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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Cancer Res. 2016 Apr 13;76(11):3211–3223. doi: 10.1158/0008-5472.CAN-15-0025

Figure 1. Medulloblastomas in M-Smo mice are radiation sensitive.

Figure 1

A,A’) Kaplan Meier curves demosntrated that xRT extends the survival of medulloblastoma-bearing mice. B–E) H&E stained sections of representative tumors harvested at the indicated interval after xRT. Tumors reduction is detectable 24 hours after xRT and is maximal by 5 days. F–I) IHC for γH2AX shows that cells with detectable DNA damage are rare in untreated tumors; xRT induces homogeneous γH2AX expression at 4 hours after xRT, that resolves by 24 hours. J–M) IHC for cC3 shows that apoptotic cells are rare in untreated tumors. Radiation induces widespread apoptosis by 4 hours after treatment. Apoptosis continues through 24 hours after xRT. By 5 days, apoptotic cells are rare within the residual tissue that persists after xRT. Scale bars are 1mm in low power images and 20 µm in insets.