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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Cancer Res. 2016 Mar 31;76(11):3351–3363. doi: 10.1158/0008-5472.CAN-15-2268

Figure 7.

Figure 7

Illustration depicting p120 catenin regulation of epithelial cell extrusion. a) p120 catenin loss in adult pancreatic acinar cells in the context of experimental pancreatitis promotes apical and basal epithelial cell extrusion. b) In the context of oncogenic Kras, PanIN epithelial cells extruding basally through delamination associated with EMT express less adherens junction proteins p120 catenin and E-cadherin. Mutant Kras PanIN epithelial cells deficient for p120 catenin retain epithelial morphology after extruding basally and display features of malignancy.