Skip to main content
. 2015 Dec 15;75(1):19–34. doi: 10.1093/jnen/nlv001

FIGURE 2.

FIGURE 2.

Neuronal tau pathology in cortical neurons in chronic traumatic encephalopathy (CTE). (A–L) Tissue sections from the superior frontal gyrus of CTE cases (A–D) and the temporal lobe of Alzheimer disease (AD) (E–H) and in nondemented aged control (ND) cases (I–L) were immunostained to characterize the gray matter pathology containing phosphatase-activating domain (PAD) exposed tau (TNT1-positive; A, E, I), tau oligomers (TOC1-positive; B, F, J), phospho-Ser422 tau (pS422-positive; C, G, K), and C-terminal truncated tau (TauC3-positive; D, H, L). Notably, the TNT1 (A, E), TOC1 (B, F), and pS422(C, G) tau pathology in CTE and AD included extensive neuropil threads and neurofibrillary tangles. In contrast, TNT1 (I), TOC1 (J), or pS422 (K) labeled very little to no pathology in the temporal lobe of ND control cases. The TauC3 marker was relatively sparse in CTE (D), yet abundant in AD (H) and very low in ND (L) cases. Note that the ND images are taken at a lower magnification to show larger areas and the very low levels of immunoreactivity. Scale bar in H, 50 µm for A–H; scale bar in L, 200 μm for I–L.